Dong quai is also called dang gui, tang-kuei, Chinese Angelica, or “female ginseng,” and is part of the carrot and parsley family. A sinensis is easily the most broadly used from the Angelica species, although other species are located in traditional medications of various cultures. The roots and rhizomes would be the most extensively used areas of the guarana plant. Uses and Benefits: Dong quai is a well-liked Chinese medicinal plant or Chinese healing herbs, commonly used in formulations for gynecologic disorders. Within the U.S., it’s frequently promoted like a general female tonic, labeled only for “female balance and wellness” it’s also used particularly to deal with premenstrual syndrome or pms, amenorrhea, irregular menses, dysmenorrhea, and menopause signs and symptoms. In Chinese medicine, dong quai can be used for overall health promotion, “bloodstream deficiency” conditions, as well as for many gynecologic and obstetric disorders.
Pharmacology: Important chemical ingredients considered to be inside a sinensis include ligustilide, ferulic acidity, polysaccharides, and furanocoumarins (for example psoralen). However, a current analysis unsuccessful to locate coumarins in commercial dong quai items. The biologic activity of the. Sinensis extracts continues to be looked into in an array of in vitro and animal experiments, mainly in China and Japan. Within the nineteen fifties, two different extracts shown opposing uterine muscle activity in animal models.38,9 A volatile oil element of dong quai was discovered to hinder spontaneous uterine contractions in isolated uteri (less marked effect was seen after intravenous administration to whole creatures). In comparison, a water- or alcohol-based component given intravenously increased and elevated uterine contractions in vivo. Ferulic acidity, a part of A sinensis, was discovered to possess Numerous other in vitro and animal research has been released within the Asian literature recording the pharmacological activity of dong quai extracts or isolated chemical components. Ilise include various cardiovascular, hematologic, immuno, anti-inflammatory, and analgesic effects.
However, reason for the broadly different experimental conditions, doses, animal models, it is not easy to extrapolate these effects to Iluman use. Dong quai isn’t regarded as estrogenic within the Chinese literature, 8 but modern western herbal healthcare specialists frequently ascribe estrogenic activity for this plant. In Chinese pharmacological studies, no estrojenic effects were seen on vaginal smudges of rodents, and rats brought dong quai as 5% of the diet didn’t develop elevated uterine weights. This insufficient hormonal effect is based on an in vitro U.S. study, by which dong quai didn’t bind to oestrogen receptors (ERs), nor made it happen stimulate cell proliferation in ER-positive human cancer of the breast cells. However, contrasting outcome was present in an unregistered study by which dong quai did bind to oestrogen receptors in vitro, and adding the plant towards the feed of ovariectomized rats apparently elevated uterine weight.
Clinical Tests: A properly-designed U.S. medical trial examined dong quai like a single plant to treat menopause signs and symptoms. This randomized, double-blind, placebo-controlled trial examined postmenopausal women with menopausal flashes. Subjects were randomized to treatment having a placebo or 4.5 g/day’s a standardized dong quai root product (500 mg/capsule 3 capsules t.i.d.) for twenty-four days. Subjects were examined for serum hormone levels, vaginal cell maturation, endometrial proliferation with transvaginal ultrasonography, and menopause signs and symptoms having a self-reported diary of menopausal flashes along with a menopause index score. There have been no statistically significant variations between your dong quai group and also the placebo group in almost any parameter which was examined. Participants were not able to differentiate between plant and placebo, and both groups noted similar incidence of unwanted effects (belching, gas, and headache). One small, randomized, double-blind, and placebo-controlled U.S. study examined a mix of dong quai with four other herbal treatments in 13 women with menopause signs and symptoms over 3 several weeks.
The authors reported improvement in menopause signs and symptoms, however the outcome was hard to interpret because of insufficient data and also the small study size. A Japanese double-blind, placebo-controlled trial found a mix of dong quai with five other herbal treatments to possess significant analgesic effects in 40 women with dysmenorrhea. Hormonal levels weren’t affected. Just one U.S. situation report of the decoction produced from dong quai and peony root was connected with improvement of erythropoietin-resistant anemia secondary to chronic kidney failure. Traditional dong quai (ginseng for woman) that contains formulas, in conjunction with other herbal treatments, happen to be reported within the Chinese and herbal literature to work for dysmenorrhea, amenorrhea, menopause signs and symptoms, pelvic infections, premenstrual syndrome or pms, hepatitis, chronic obstructive lung disease, chronic glomerulonephritis, along with other disorders.
Chinese doctors also have given dong quai by injection (IV, 1M, or into acupuncture sites) to deal with conditions for example discomfort syndromes, thromboangiitis obliterans, chronic pelvic infections, Raynaud’s disease, rheumatoid arthritis symptoms, stroke, and allergic rhinitis. However, the majority of this literature relies partly or completely on Chinese medicine ideas of treatment and diagnosis, which mainly out of control studies and situation series are methodologically insufficient to permit scientific evaluation of effectiveness. Negative Effects Dong quai is usually considered to have couple of, or no, negative effects. Unwanted effects weren’t not the same as placebo within the biggest controlled trial. One situation report of hypertension supported by headache, weakness, and vomiting was connected with consuming two servings of the traditional dong quai soup inside a 32-year-old lady her 3-week-old boy also had mildly elevated bloodstream pressure while breastfeeding. A expected outcomes relationship using the dong quai element of the soup is unclear.
Herbal healthcare specialists frequently condition that dong quai has mild laxative qualities, which is probably according to ancient Chinese documents it “lubricates the bowel,” however this effect hasn’t otherwise been reported. Unwanted Effects and Interactions: Two situation reviews claim that dong quai may potentiate the anticoagulant results of warfarin. A 46-year-old lady therapeutically maintained on warfarin possessed a two-fold elevation from the worldwide stabilized ratio (INR) after taking 1-2 pills daily of dong quai (565 mg/tab Nature’s Way), Wllich resolved over several days after discontinuation from the herd. Another patient stable on warfarin for ten years given common bruising as well as an INR of 101 month after beginning dong quai for menopause signs and symptoms particulars of the situation ,aren’t provided.
Cautions: According to animal experiments, Chinese researchers happen to be concerned that dong quai may similarly modify the Iiterus and bloodstream coagulation of humans, and therefore suggest that it’s prevented at the begining of pregnancy, bleeding disorders, and menorrhagia. Because dong quai could have furanocoumarins (e.g., psoralen), some believe that customers ought to be informed about potential photosensitization (from time to time observed in persons collecting plants which contain these chemicals), as well as concerning the potential photocarcinogenic or mutagenic results of psoralens. However, to place this within the proper perspective, these chemicals will also be present in many edible plants, for example parsnip, celery, and parsley. Ingestion of huge amounts could raise the chance of phototoxicity in patients going through treatment with psoralen ultraviolet A (PUVA) however, a current analysis unsuccessful to locate furanocoumarins in dong quai items. Formulations & Doses: The daily dose of dong quai recommended by professionals of Chinese herbs woman health is generally 4-15 g, given because the whole root or root slices. Dong quai is typically in combination with a number of other herbal treatments, frequently prepared in teas, sauces, or any other dishes, but commercial items can be found in a number of powdered root or extract formulations. United States customers can buy dong quai like a single or combination herbal preparation that consists of about 100-500 mg of root or root extract per dosage form, with a multitude of suggested dosing regimens.
Summary Evaluation: Advantageous claims for dong quai are based mainly on ideas of Chinese healing, in vitro and animal studies, and out of control clinical tests and situation series-which suggest advantageous effects but they are methodologically insufficient to determine effectiveness. The only real well-designed, controlled medical trial of dong quai used by itself didn’t demonstrate any estrogenic activity or benefits for menopause signs and symptoms, and therefore there’s no high-quality evidence to aid its use. Using Chinese angelica in conjunction with other herbal treatments continues to be examined in couple of adequately controlled, clinical tests. According to lengthy historic use and limited studies, female ginseng seems safe and well tolerated.